Description
MDGA2 is a 130 kDamember of the Ig superfamily of proteins. Human MDGA2 is synthesized as a 956amino acid (aa) precursor that contains a 25 aa signal sequence, a 906 aamature chain, and a 25 aa propeptide. The mature chain consists of sixIg-like domains, followed by a MAM domain (aa 746-921) and a GPI anchor. Inaddition, there are eight potential sites for N-linked glycosylation. Maturehuman MDGA2 shares 98% aa sequence identity with mature mouse and rat MDGA2.MDGA2 is structurally similar to other IgCAMS, such as the L1 family andaxonin 1, which have roles in cell adhesion, migration, and processoutgrowth